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A model that integrates the different piRNA biogenesis pathways based on studies in silkworm BmN4 cells

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oxidation of iodide, iodination of tyrosine residues of thyroglobulin (Tg), and the oxidative coupling of iodinated tyrosine residues to generate Tg-bound TH, are catalyzed by the enzyme thyroid peroxidase (TPO), which is located in the apical membrane of the thyrocyte generating hydrogen peroxide (H2O2) as a substrate [61, 62]